Job Description

<h3>Are you an experienced Senior Scientist with a background in cell biology and assay development? Do you like innovative approaches and do you have a passion about the possibilities of science to change lives? Perfect, this position might be your next challenge at AstraZeneca!</h3> <p>We are looking for a motivated and engaged <strong>Senior Scientist</strong> to join our <strong>Oligo Cell Assay Development team</strong> at <strong>AstraZeneca</strong> in <strong>Gothenburg</strong>. As a Senior Scientist in oligo cellular assay development, you will use your knowledge of cells and assay technologies to develop state-of-the-art cell-based assays for screening and profiling of potential therapeutic oligos such as antisense oligonucleotides or siRNA, with the aim to identify lead molecules. You will contribute to the progression of drug projects by bringing novel ideas and scientific strategy. You will work within Discovery Sciences, part of AstraZeneca's BioPharmaceuticals organisation, with a focus on scientific advances in drug discovery across therapeutic areas including, respiratory and inflammation (R&I), cardiovascular, renal and metabolism (CVRM) and rare disease (Alexion).</p> <h3>What you will do</h3> <p>This is an exciting opportunity for you to join us as a lab-based scientist to develop cell assays for discovery of novel oligonucleotide-based therapies. The assays you develop will be used in projects in all phases of AstraZeneca's drug discovery pipeline. You will work closely with our colleagues in the Cell engineering and Cell banking teams, screening scientists in the oligo profiling team, and the rest of the AstraZeneca therapeutic oligo platform.</p> <p>We believe that our new colleague is a highly motivated scientist with a keen interest in technological and scientific advances. Along with this, we see you as a person who enjoys collaboration, who holds networking skills with experience of interacting effectively across functions and disciplines. This goes hand in hand with your problem-solving skills, great goal focus, and enthusiasm for science.</p> <p>You will be strongly encouraged and supported to think creatively in our dynamic environment. Here, we are free from fear of failure, free to ask the right questions, and make bold decisions.</p> <h3>Essential for the role</h3> <ul> <li>PhD in Biology, Pharmacology, Cell biology or a related discipline or a BSc/MSc degree with significant relevant experience, preferably in the pharmaceutical or biotechnology industry.</li> <li>Highly skilled in cellular biology techniques applied to develop cell-based assays.</li> <li>Extensive experience in the development and application of assays for quantitative measurements of RNA transcripts.</li> <li>Experience with therapeutic oligonucleotides (e.g. ASOs or siRNAs).</li> <li>Experienced in working with many and diverse cell models.</li> <li>First-rate analysis and decision-making skills, coupled with a tenacity to see decisions through, even in situations of ambiguity.</li> </ul> <h3>Desirable for the role</h3> <ul> <li>Expertise in a range of cell biology techniques, including cloning, transfection methods, and gene expression knock-down (RNAi or other).</li> <li>Experience in the design, development and validation of cellular assays for compound screening and /or profiling.</li> <li>Cellular imaging and image analysis experience.</li> <li>Experience with automation for cell assays.</li> </ul> <p><strong>Why AstraZeneca?</strong> Thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. This is the place to go beyond discovery – we think holistically about patients and are always learning from those living with diseases.</p> <h3>So, what's next?</h3> <p>If this sounds like the role and place for you – welcome to apply today! Send your application as soon as possible, but no later than <strong>August 11, 2024</strong>.</p> <p>For further details around this position, you are welcome to contact the recruiting manager Karl-Johan Leuchowius, karl-johan.leuchowius@astrazeneca.com</p> <h3>Additional information</h3> <ul> <li>Our Gothenburg site: <a href='https://www.astrazeneca.com/our-science/gothenburg.html'>https://www.astrazeneca.com/our-science/gothenburg.html</a></li> <li>Life in Gothenburg: <a href='https://www.movetogothenburg.com/'>https://www.movetogothenburg.com/</a></li> <li>Make a move to Global Gothenburg: <a href='https://www.youtube.com/watch?v=c-Iqbb4aw38'>https://www.youtube.com/watch?v=c-Iqbb4aw38</a></li> <li>About BioPharmaceuticals R&D: <a href='https://www.astrazeneca.com/r-d.html'>https://www.astrazeneca.com/r-d.html</a></li> </ul>